Mineralocorticoid receptor

NR3C2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y9R, 1YA3, 2A3I, 2AA2, 2AA5, 2AA6, 2AA7, 2AAX, 2AB2, 2ABI, 2OAX, 3VHU, 3VHV, 3WFF, 3WFG, 4PF3, 4TNT, 4UDB, 4UDA, 5HCV
Identifiers
Aliases	NR3C2, MCR, MLR, MR, NR3C2VIT, nuclear receptor subfamily 3 group C member 2
External IDs	OMIM: 600983; MGI: 99459; HomoloGene: 121495; GeneCards: NR3C2; OMA:NR3C2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.23 Start 148,078,762 bp[1] End 148,444,698 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C1|8 36.34 cM Start 77,626,070 bp[2] End 77,971,641 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell mucosa of colon mucosa of sigmoid colon rectum middle temporal gyrus Epithelium of choroid plexus mucosa of ileum Brodmann area 23 Achilles tendon jejunal mucosa Top expressed in subdivision of hippocampus Region I of hippocampus proper hippocampus proper left colon lateral septal nucleus dentate gyrus facial motor nucleus ciliary body subiculum dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity zinc ion binding metal ion binding steroid hormone receptor activity steroid binding protein binding lipid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm endoplasmic reticulum membrane membrane receptor complex endoplasmic reticulum nucleus nucleoplasm cytosol Biological process regulation of transcription, DNA-templated transcription, DNA-templated transcription initiation from RNA polymerase II promoter signal transduction steroid hormone mediated signaling pathway regulation of transcription by RNA polymerase II positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4306 110784 Ensembl ENSG00000151623 ENSMUSG00000031618 UniProt P08235 Q8VII8 RefSeq (mRNA) NM_000901 NM_001166104 NM_001354819 NM_001083906 RefSeq (protein) NP_000892 NP_001159576 NP_001341748 n/a Location (UCSC) Chr 4: 148.08 – 148.44 Mb Chr 8: 77.63 – 77.97 Mb PubMed search [3] [4]
Wikidata
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The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2.^[5]

MR is a receptor with equal affinity for mineralocorticoids and glucocorticoids. It belongs to the nuclear receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus. The selective response of some tissues and organs to mineralocorticoids over glucocorticoids occurs because mineralocorticoid-responsive cells express Corticosteroid 11-beta-dehydrogenase isozyme 2, an enzyme which selectively inactivates glucocorticoids more readily than mineralocorticoids.