Clinical data | |
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Trade names | Sernyl, Sernylan (both discontinued) |
Other names | CI-395; Phenylcyclohexylpiperidine; "Angel dust"[1] |
AHFS/Drugs.com | phencyclidine |
Dependence liability | Physical: Low Psychological: Moderate[2] |
Addiction liability | Variable, reported from low to high[3][4] |
Drug class | NMDA receptor antagonists; General anesthetics; Dissociative hallucinogens[5] |
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Pharmacokinetic data | |
Metabolism | Oxidative hydroxylation in liver by CYP450 enzymes, glucuronidation |
Metabolites | PCHP, PPC, PCAA |
Onset of action | 2–60 min[6] |
Elimination half-life | 7–46 hours |
Duration of action | 6–48 hours[6] |
Excretion | Urine |
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ECHA InfoCard | 100.150.427 |
Chemical and physical data | |
Formula | C17H25N |
Molar mass | 243.394 g·mol−1 |
3D model (JSmol) | |
Melting point | 46.5 °C (115.7 °F) |
Boiling point | 136 °C (277 °F) |
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Phencyclidine (data page) | |
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Phencyclidine or phenylcyclohexyl piperidine (PCP), also known in its use as a street drug as angel dust among other names, is a dissociative anesthetic mainly used recreationally for its significant mind-altering effects.[1][5] PCP may cause hallucinations, distorted perceptions of sounds, and violent behavior.[5][8][9] As a recreational drug, it is typically smoked, but may be taken by mouth, snorted, or injected.[5][7][8] It may also be mixed with cannabis or tobacco.[1][5]
Adverse effects may include seizures, coma, addiction, and an increased risk of suicide.[8] Flashbacks may occur despite stopping usage.[9] Chemically, PCP is a member of the arylcyclohexylamine class, and pharmacologically, it is a dissociative anesthetic.[5][10][11] PCP works primarily as an NMDA receptor antagonist.[10]
PCP is most commonly used in the United States.[12] While usage peaked in the US in the 1970s,[13] between 2005 and 2011 an increase in visits to emergency departments as a result of the drug occurred.[8] As of 2017 in the United States, about 1% of people in 12th grade reported using PCP in the prior year while 2.9% of those over the age of 25 reported using it at some point in their lives.[14]
high abuse liability
NHM-PCP and ketamine
was invoked but never defined (see the help page).high abuse liability
PCP can lead to hostile behavior that may result in episodes of extreme violence