Aromataza

CYP19A1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 3EQM, 3S79, 3S7S, 4GL5, 4GL7, 4KQ8
Identifikatori
Aliasi	CYP19A1
Vanjski ID-jevi	OMIM: 107910 MGI: 88587 HomoloGene: 30955 GeneCards: CYP19A1
Lokacija gena (čovjek) Hrom. Hromosom 15 (čovjek)[1] Bend 15q21.2 Početak 51,208,057 bp[1] Kraj 51,338,601 bp[1]
Lokacija gena (miš) Hrom. Hromosom 9 (miš)[2] Bend 9 A5.3|9 29.49 cM Početak 54,073,221 bp[2] Kraj 54,175,394 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • iron ion binding • oxygen binding • vezivanje iona metala • monooxygenase activity • heme binding • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • electron transfer activity • oxidoreductase activity • aromatase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • steroid hydroxylase activity Ćelijska komponenta • endoplasmic reticulum membrane • Endoplazmatski retikulum • membrana • integral component of membrane Biološki proces • estrogen biosynthetic process • androgen metabolic process • negative regulation of chronic inflammatory response • prostate gland growth • sterol metabolic process • negative regulation of macrophage chemotaxis • steroid biosynthetic process • female gonad development • female genitalia development • mammary gland development • uterus development • testosterone biosynthetic process • androgen catabolic process • positive regulation of estradiol secretion • Lanac transporta elektrona Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	1588	13075
Ensembl	ENSG00000137869	ENSMUSG00000032274
UniProt	P11511	P28649
RefSeq (mRNK)	NM_000103 NM_001347248 NM_001347249 NM_001347250 NM_001347251 NM_001347252 NM_001347253 NM_001347254 NM_001347255 NM_001347256 NM_031226	NM_007810 NM_001348171 NM_001348172 NM_001348173
RefSeq (bjelančevina)	NP_000094 NP_001334177 NP_001334178 NP_001334179 NP_001334180 NP_001334181 NP_001334182 NP_001334183 NP_001334184 NP_001334185 NP_112503	NP_001335100 NP_001335101 NP_001335102 NP_031836
Lokacija (UCSC)	Chr 15: 51.21 – 51.34 Mb	Chr 9: 54.07 – 54.18 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aromataza, također zvana i estrogen-sintetaza ili estrogen-sintaza, je enzim odgovoran za ključni korak u biosintezi estrogena. To je CYP19A1, član superporodice citohrom P450 (EC broj | 1.14.14.1), u kojoj su monooksigenaze – katalizatori mnogih reakcije, uključenih u steroidogenezu. Aromataza je posebno odgovorna za aromatizaciju androgena u estrogene. Enzim aromataza može se naći u mnogim tkivima, uključujući gonade (granulozne ćelije, mozak, masno tkivo, placenta, krvni sudovi, koža i kosti, kao i u tkivima endometrioze, mioma maternice, raka dojke i raka endometrija. Važan je faktor u seksualnom razvoju.

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000137869 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000032274 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.