Receptor D4 de dopamina

DRD4
Identificadores
Nomes alternativos	DRD4
IDs externos	OMIM: 126452 HomoloGene: 20215 GeneCards: DRD4
Targeted by Drug
	PF-592379, Rotigotina, A-412997, ABT-670, dopamina, fenoldopam, quinpirole, WAY-100635, apomorfina, cabergolina, lisurida, pergolide, roxindole, bromocriptina, (+)-butaclamol, clorpromazina, clozapina, eticlopride, haloperidol, L745870, loxapina, 5-chloro-2-methoxy-4-(methylamino)-N-(2-methyl-1-(phenylmethyl)-3-pyrrolidinyl)benzamide, perospirone, piribedil, Proclorperazina, sertindole, sonepiprazole, espiperona, levosulpiride, Tergurida, trifluoperazina, zotepina, pimozida, droperidol, haloperidol, apomorfina, thioridazine hydrochloride, bromocriptine mesylate, chlorpromazine hydrochloride, pergolide mesylate, promazine hydrochloride
Ontologia genética
Função molecular	• signal transducer activity; • potassium channel regulator activity; • SH3 domain binding; • identical protein binding; • dopamine neurotransmitter receptor activity; • G protein-coupled receptor activity; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • dopamine binding; • dopamine neurotransmitter receptor activity, coupled via Gi/Go; • epinephrine binding; • norepinephrine binding; • metal ion binding; • G protein-coupled serotonin receptor activity; • neurotransmitter receptor activity;
Componente celular	• integral component of membrane; • integral component of plasma membrane; • membrane; • membrana plasmática; • postsynapse; • glutamatergic synapse; • dendrito;
Processo biológico	• response to amphetamine; • rhythmic process; • arachidonic acid secretion; • regulation of circadian rhythm; • positive regulation of dopamine uptake involved in synaptic transmission; • GO:0072468 transdução de sinal; • fear response; • dopamine metabolic process; • behavioral response to ethanol; • behavioral response to cocaine; • positive regulation of sodium:proton antiporter activity; • cellular calcium ion homeostasis; • positive regulation of kinase activity; • adult locomotory behavior; • potencial pós-sináptico inibitório; • negative regulation of protein secretion; • comportamento social; • negative regulation of voltage-gated calcium channel activity; • regulation of dopamine metabolic process; • response to histamine; • behavioral fear response; • dopamine receptor signaling pathway; • G protein-coupled receptor signaling pathway; • adenylate cyclase-inhibiting dopamine receptor signaling pathway; • regulation of postsynaptic neurotransmitter receptor internalization; • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • chemical synaptic transmission; • G protein-coupled serotonin receptor signaling pathway;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	1815
	n/a
	ENSG00000069696; ENSG00000276825
	n/a
	P21917
	n/a
	NM_000797
	n/a
	NP_000788
	n/a
	Wikidata
Ver/Editar Humano

O receptor D₄ de dopamina é um receptor acoplado à proteína G, codificado pelo gene DRD4.^[3] Tal como outros tipos de receptores de dopamina, o receptor D₄ é activado pelo neurotransmissor dopamina. É também um alvo para drogas que tratam a esquizofrenia e a doença de Parkinson.

O receptor D₄ é considerado um Receptor D2 de dopamina, no qual o receptor activado inibe a enzima adenilato ciclase, reduzindo assim a concentração intracelular do mensageiro secundário AMP cíclico.^[4]

Referências

↑ «Drogas que interagem fisicamente com Dopamine receptor D4 ver/editar referências no wikidata»
↑ «Human PubMed Reference:»
↑ Van Tol HH, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB, Civelli O (1991). «Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine». Nature. 350 (6319): 610–4. PMID 1840645. doi:10.1038/350610a0
↑ Neve KA, Seamans JK, Trantham-Davidson H (2004). «Dopamine receptor signaling». J. Recept. Signal Transduct. Res. 24 (3): 165–205. PMID 15521361

[1] «Drogas que interagem fisicamente com Dopamine receptor D4 ver/editar referências no wikidata»

[2] «Human PubMed Reference:»

[pmid1840645-3] Van Tol HH, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB, Civelli O (1991). «Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine». Nature. 350 (6319): 610–4. PMID 1840645. doi:10.1038/350610a0

[pmid15521361-4] Neve KA, Seamans JK, Trantham-Davidson H (2004). «Dopamine receptor signaling». J. Recept. Signal Transduct. Res. 24 (3): 165–205. PMID 15521361

[1]

[2]

[3]

[4]

Our website is made possible by displaying online advertisements to our visitors. Please consider supporting us by disabling your ad blocker.

Receptor D4 de dopamina

Referências

Our website is made possible by displaying online advertisements to our visitors.
Please consider supporting us by disabling your ad blocker.