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Serotonin
 | |
| Data klinikal | |
|---|---|
| Nama lain | 5-HT, 5-Hidroksitriptamina, Enteramina, Trombositin, 3-(β-Aminoetil)-5-hidroksiindol, Trombotonin |
| Data fisiologi | |
| Sumber tisu | Nukleus rafe, sel enterokromafin |
| Tisu sasaran | Seluruh sistem |
| Reseptor | 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7 |
| Agonis | Tak terus: SSRI, MAOI |
| Pelopor | 5-HTP |
| Biosintesis | Dekarboksilase asid L-amino aromatik |
| Metabolisme | MAO |
| Pengecam | |
| |
| Nombor CAS | |
| PubChem CID | |
| IUPHAR/BPS | |
| ChemSpider | |
| KEGG | |
| Ligan PDB | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.000.054 |
| |
| Nama | |
|---|---|
| Nama IUPAC
5-Hidroksitriptamina
| |
| Nama IUPAC pilihan
3-(2-Aminoetil)-1H-indol-5-ol | |
| Nama lain
5-HT, 5-Hidroksitriptamina, Enteramina, Trombositin, 3-(β-Aminoetil)-5-hidroksiindol, Trombotonin
| |
| Pengecam | |
Imej model 3D Jmol
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| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.000.054 |
| KEGG | |
| MeSH | Serotonin |
PubChem CID
|
|
| UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
| Sifat | |
| C10H12N2O | |
| Jisim molar | 176.215 g/mol |
| Rupa bentuk | Serbuk putih |
| Takat lebur | 167.7 °C (333.9 °F; 440.8 K) 121–122 °C (ligroin)[3] |
| Takat didih | 416 ± 30 °C (pada 760 Torr)[1] |
| Sedikit larut | |
| Keasidan (pKa) | 10.16 dalam air pada 23.5 °C[2] |
| Momen dwikutub | 2.98 D |
| Bahaya | |
| MSDS | External MSDS |
| Dos maut (LD) atau kepekatan dos maut (LC) | |
LD50 (median dos)
|
750 mg/kg (subkutaneus, tikus),[4] 4500 mg/kg (intraperitoneal, tikus),[5] 60 mg/kg (oral, tikus) |
Kecuali jika dinyatakan sebaliknya, data diberikan untuk bahan-bahan dalam keadaan piawainya (pada 25 °C [77 °F], 100 kPa). | |
 pengesahan (apa yang perlu:  / ?)
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| Rujukan kotak info | |
Serotonin (5-hidroksitriptamina; 5-HT) ialah suatu pengutus saraf monoamino yang disintesiskan pada neuron-neuron serotonergis dalam sistem saraf pusat dan sel-sel enterokromafin dalam saluran pencernaan. Hormon ini dipercaya sebagai pemberi perasaan selesa dan senang.[6]
- ^ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994–2011 ACD/Labs)
- ^ Mazák K, Dóczy V, Kökösi J, Noszál B (April 2009). "Proton speciation and microspeciation of serotonin and 5-hydroxytryptophan". Chemistry & Biodiversity. 6 (4): 578–590. doi:10.1002/cbdv.200800087. PMID 19353542. S2CID 20543931.
- ^ Pietra S (1958). "[Indolic derivatives. II. A new way to synthesize serotonin]". Il Farmaco; Edizione Scientifica (dalam bahasa Itali). 13 (1): 75–79. PMID 13524273.
- ^ Erspamer V (1952). "Ricerche preliminari sulle indolalchilamine e sulle fenilalchilamine degli estratti di pelle di Anfibio". Ricerca Scientifica. 22: 694–702.
- ^ Tammisto T (1967). "Increased toxicity of 5-hydroxytryptamine by ethanol in rats and mice". Annales Medicinae Experimentalis et Biologiae Fenniae. 46 (3): 382–384. PMID 5734241.
- ^ Young SN (2007). "How to increase serotonin in the human brain without drugs". Rev. Psychiatr. Neurosci. 32 (6): 394–99. PMID 18043762.
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