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Etoposido

Etoposido
Formula kimikoaC29H32O13
SMILES kanonikoa2D eredua
SMILES isomerikoa
C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O
MolView3D eredua
Mota[[(5S,5aR,8aR,9R)-5-[(7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one|(5S,5aR,8aR,9R)-5-[(7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one]] (en) Itzuli eta [[(8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one|(8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one]] (en) Itzuli
Estereoisomeroa[[(5S,5aS,8aS,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one|(5S,5aS,8aS,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one]] (en) Itzuli
Masa molekularra588,184 Da
Erabilera
Konposatu aktiboaToposar (en) Itzuli eta Etopophos (en) Itzuli
Tratatzen duNeuroblastoma, testicular cancer (en) Itzuli, garuneko minbizi, mikosi fungoide, trophoblastic neoplasm (en) Itzuli, Ewingen sarkoma, histiozitosi, lung benign neoplasm (en) Itzuli, prostatako minbizi, umetokiko minbizi, Kaposiren sarkoma, acute myeloid leukemia (en) Itzuli, errabdomiosarkoma, maxkuriko minbizi, linfoma, germ cell cancer (en) Itzuli, B-cell lymphoma (en) Itzuli, ez-Hodgkin linfoma, testicular malignant germ cell cancer (en) Itzuli, Hezur sarkoma, neuroblastoma, susceptibility to (en) Itzuli, diffuse large B-cell lymphoma (en) Itzuli, testicular cancer (en) Itzuli eta lung small cell carcinoma (en) Itzuli
Interakzioakziklosporina
ElkarrekintzaDNA topoisomerase II alpha (en) Itzuli
Hartzeko bideaintravenous infusion and defusion (en) Itzuli eta aho emate
HaurdunaldiaAustralian pregnancy category D (en) Itzuli eta US pregnancy category D (en) Itzuli
RolaDNA polymerase inhibitors (en) Itzuli, topoisomerase inhibitor (en) Itzuli, phytogenic antineoplastic agents (en) Itzuli, topoisomerase II inhibitor (en) Itzuli, developmental toxicant (en) Itzuli, kantzerigeno eta farmako esentzial
Identifikatzaileak
InChlKeyVJJPUSNTGOMMGY-MRVIYFEKSA-N
CAS zenbakia33419-42-0
ChemSpider33510
PubChem36462
Gmelin4911
ChEMBLCHEMBL44657
EC zenbakia251-509-1
ECHA100.046.812
MeSHD005047
RxNorm4179
Human Metabolome DatabaseHMDB0014911
UNII6PLQ3CP4P3
NDF-RTN0000146478
KEGGC01576 eta D00125
PDB LigandEVP
Ohar medikoa
Ohar medikoa
Oharra: Wikipediak ez du mediku aholkurik ematen. Tratamendua behar duzula uste baduzu, jo ezazu sendagilearengana.

Etoposidoa, VP-16 bezala ere ezaguna, podofilina erdiintetiko bat da, Podophyllum landaretik eratorria. Tumore-zelulen ugalketa inhibitzeko duen gaitasunagatik minbizi mota batzuk tratatzeko erabiltzen dute.

Banaketa azkarreko zelula osasuntsu batzuetan ere eragin dezake, hala nola odolaren, digestio-aparatuaren edo ilearen zeluletan, eta, beraz, albo-ondorio kaltegarriak ere sortzen ditu.

Etoposidoa 1983an merkaturatu zuten.[1]

  1. (Ingelesez) Fischer, Janos; Ganellin, C. Robin. (2006). Analogue-based Drug Discovery. John Wiley & Sons, 489 or. ISBN 9783527607495..

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إيتوبوسيد Arabic Etoposid CY Etoposid German Ετοποσίδη Greek Etoposide English Etopósido Spanish اتوپوساید FA Etoposidi Finnish Étoposide French אטופוסיד HE

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