Multidrug resistance-associated protein 2

ABCC2
Identifiers
Aliases	ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP, Multidrug resistance-associated protein 2, ATP binding cassette subfamily C member 2
External IDs	OMIM: 601107; MGI: 1352447; HomoloGene: 68052; GeneCards: ABCC2; OMA:ABCC2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.2 Start 99,782,640 bp[1] End 99,852,594 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 36.67 cM Start 43,770,631 bp[2] End 43,829,179 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver jejunal mucosa gallbladder duodenum human kidney mucosa of ileum testicle tibial nerve gonad sural nerve Top expressed in left lobe of liver duodenum right kidney proximal tubule jejunum human kidney yolk sac epithelium of small intestine ileum migratory enteric neural crest cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase activity nucleotide binding protein binding ATP binding transporter activity protein domain specific binding ATPase-coupled transmembrane transporter activity organic anion transmembrane transporter activity ATPase-coupled inorganic anion transmembrane transporter activity bilirubin transmembrane transporter activity transmembrane transporter activity Cellular component integral component of membrane membrane cell surface plasma membrane apical plasma membrane brush border membrane intercellular canaliculus integral component of plasma membrane Biological process response to steroid hormone response to arsenic-containing substance prostaglandin transport response to methotrexate thyroid hormone transport xenobiotic transmembrane transport transmembrane transport cellular chloride ion homeostasis response to oxidative stress response to estrogen response to heat bilirubin transport female pregnancy mercury ion transport canalicular bile acid transport antibiotic metabolic process cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to dexamethasone stimulus response to antineoplastic agent benzylpenicillin metabolic process cellular response to hormone stimulus transport organic anion transport response to lipopolysaccharide response to glucagon Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1244 12780 Ensembl ENSG00000023839 ENSMUSG00000025194 UniProt Q92887 Q8VI47 RefSeq (mRNA) NM_000392 NM_013806 RefSeq (protein) NP_000383 NP_038834 Location (UCSC) Chr 10: 99.78 – 99.85 Mb Chr 19: 43.77 – 43.83 Mb PubMed search [3] [4]
Wikidata
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Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATP-binding cassette sub-family C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 gene.^[5][6][7]