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Chromatin structure remodeling (RSC) complex
RSC (Remodeling the Structure of Chromatin) is a member of the ATP-dependent chromatin remodeler family. The activity of the RSC complex allows for chromatin to be remodeled by altering the structure of the nucleosome.[1]
There are four subfamilies of chromatin remodelers: SWI/SNF, INO80, ISW1, and CHD.[2] The RSC complex is a 15-subunit chromatin remodeling complex initially found in Saccharomyces cerevisiae, and is homologous to the SWI/SNF complex found in humans.[1] The RSC complex has ATPase activity in the presence of DNA.[1]
- ^ a b c Cairns BR, Lorch Y, Li Y, Zhang M, Lacomis L, Erdjument-Bromage H, et al. (December 1996). "RSC, an essential, abundant chromatin-remodeling complex". Cell. 87 (7): 1249–60. doi:10.1016/S0092-8674(00)81820-6. PMID 8980231.
- ^ Clapier CR, Iwasa J, Cairns BR, Peterson CL (July 2017). "Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes". Nature Reviews. Molecular Cell Biology. 18 (7): 407–422. doi:10.1038/nrm.2017.26. PMC 8127953. PMID 28512350.
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