Calcitonin

CALCA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JXZ,%%s1LS7
Identifiers
Aliases	CALCA, CT, CGRP-I, CGRP-alpha, KC, PCT, calcitonin related polypeptide alpha, CGRP, CGRP1, CALC1
External IDs	OMIM: 114130; MGI: 2151253; HomoloGene: 88401; GeneCards: CALCA; OMA:CALCA - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.2 Start 14,966,668 bp[1] End 14,972,351 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F1|7 59.99 cM Start 114,230,713 bp[2] End 114,235,592 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spinal ganglia trigeminal ganglion quadriceps femoris muscle vastus lateralis muscle cerebellar vermis islet of Langerhans human kidney Epithelium of choroid plexus tibialis anterior muscle right lobe of liver Top expressed in facial motor nucleus motor neuron lumbar spinal ganglion anterior horn of spinal cord lactiferous gland trachea trigeminal ganglion embryo embryo vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hormone activity calcitonin receptor binding protein binding identical protein binding signaling receptor binding protein-containing complex binding Cellular component cytoplasm intracellular anatomical structure extracellular region axon terminal bouton neuronal cell body neuron projection nucleus extracellular space Biological process cellular response to nerve growth factor stimulus positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway negative regulation of smooth muscle contraction regulation of heart contraction monocyte chemotaxis negative regulation of blood pressure positive regulation of cytosolic calcium ion concentration cellular response to tumor necrosis factor human ageing vasodilation cellular calcium ion homeostasis response to heat negative regulation of nervous system process positive regulation of ossification activation of adenylate cyclase activity regulation of heart rate detection of temperature stimulus involved in sensory perception of pain negative regulation of ossification response to pain artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure feeding behavior inflammatory response neuropeptide signaling pathway negative regulation of transcription, DNA-templated activation of protein kinase activity embryo implantation negative regulation of bone resorption regulation of signaling receptor activity G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of cytosolic calcium ion concentration leukocyte cell-cell adhesion G protein-coupled receptor internalization positive regulation of interleukin-1 alpha production response to yeast negative regulation of osteoclast differentiation cell-cell signaling antibacterial humoral response positive regulation of macrophage differentiation receptor internalization regulation of blood pressure protein phosphorylation vasculature development defense response to Gram-negative bacterium endothelial cell proliferation positive regulation of interleukin-8 production nervous system process involved in regulation of systemic arterial blood pressure negative regulation of calcium ion transport into cytosol innate immune response endothelial cell migration antifungal humoral response defense response to Gram-positive bacterium antimicrobial humoral immune response mediated by antimicrobial peptide amylin receptor signaling pathway calcitonin gene-related peptide receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 796 12310 Ensembl ENSG00000110680 ENSMUSG00000030669 UniProt P06881 P70160 Q99JA0 RefSeq (mRNA) NM_001033952 NM_001033953 NM_001741 NM_001378949 NM_001378950 NM_001033954 NM_007587 NM_001289444 NM_001305616 RefSeq (protein) NP_001029125.1 NP_001029126 NP_001276373 NP_001292545 NP_031613 NP_001029126.1 NP_001276373.1 Location (UCSC) Chr 11: 14.97 – 14.97 Mb Chr 7: 114.23 – 114.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid (or endostyle) in humans and other chordates^[5] in the ultimopharyngeal body.^[6] It acts to reduce blood calcium (Ca²⁺), opposing the effects of parathyroid hormone (PTH).^[7]

Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the regulation of normal calcium homeostasis.^[8] It belongs to the calcitonin-like protein family.

Historically calcitonin has also been called thyrocalcitonin.^[9]