The 2021 Central League Climax Series (CLCS) was a set of two consecutive playoff series in Nippon Professional Baseball (NPB). The First Stage began on November 6 and the Final Stage concluded on November 12. The First Stage was a best-of-three series between the second-place Hanshin Tigers and the third-place Yomiuri Giants. The Final Series was a best-of-six with the Tokyo Yakult Swallows, the Central League champion, being awarded a one-win advantage against the Giants, the winner of the First Stage. The Swallows advanced to the 2021 Japan Series to compete against the Orix Buffaloes, the 2021 Pacific League Climax Series winner.
