Back تولتيرودين Arabic تولترودین AZB Tolterodin CY Tolterodin German Τολτεροδίνη Greek Tolterodina Spanish Tolterodina EU تولترودین FA Tolterodiini Finnish Toltérodine French

Tolterodine

Tolterodine
Clinical data
Trade namesDetrol, Detrusitol, others
Other namesPNU-200583E
AHFS/Drugs.comMonograph
MedlinePlusa699026
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability77%
Protein bindingApproximately 96.3%
Elimination half-life1.9–3.7 hours
Identifiers
  • (S)-2-[3-(Diisopropylamino)-1-phenylpropyl]-4-methylphenol
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.232.068 Edit this at Wikidata
Chemical and physical data
FormulaC22H31NO
Molar mass325.496 g·mol−1
3D model (JSmol)
  • Cc1ccc(c(c1)[C@H](CCN(C(C)C)C(C)C)c2ccccc2)O
  • InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1 checkY
  • Key:OOGJQPCLVADCPB-HXUWFJFHSA-N checkY
  (verify)

Tolterodine, sold under the brand name Detrol among others, is a medication used to treat frequent urination, urinary incontinence, or urinary urgency.[5] Effects are seen within an hour.[6] It is taken by mouth.[6][7]

Common side effects include headache, dry mouth, constipation, and dizziness.[6] Serious side effects may include angioedema, urinary retention, and QT prolongation.[6] Use in pregnancy and breastfeeding are of unclear safety.[5][8] It works by blocking muscarinic receptors in the bladder thus decreasing bladder contractions.[6]

Tolterodine was approved for medical use in 1998.[6] It is available as a generic medication.[5] In 2020, it was the 271st most commonly prescribed medication in the United States, with more than 1 million prescriptions.[9][10]

  1. ^ "Detrusitol 1mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 9 March 2021. Retrieved 12 May 2022.
  2. ^ "Detrol- tolterodine tartrate tablet, film coated". DailyMed. 29 September 2021. Retrieved 12 May 2022.
  3. ^ "Detrol LA- tolterodine tartrate capsule, extended release". DailyMed. 12 October 2020. Retrieved 12 May 2022.
  4. ^ "List of nationally authorised medicinal products" (PDF). ema.europa.eu. 5 May 2022. Retrieved 9 November 2023.
  5. ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 762. ISBN 9780857113382.
  6. ^ a b c d e f "Tolterodine Tartrate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
  7. ^ Narain S, Parmar M (January 2021). "Tolterodine". StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. PMID 32491781.
  8. ^ "Tolterodine Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
  9. ^ "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
  10. ^ "Tolterodine - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.

Tolterodine

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