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LPAR6
| Receptor lizofosfatidne kiseline 6 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | LPAR6; MGC120358; P2Y5; P2RY5 | ||||||||||
| Vanjski ID | OMIM: 609239 MGI: 1914418 HomoloGene: 55925 IUPHAR: GeneCards: LPAR6 Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 10161 | 67168 | |||||||||
| Ensembl | ENSG00000139679 | ENSMUSG00000033446 | |||||||||
| UniProt | P43657 | Q8BMC0 | |||||||||
| RefSeq (mRNA) | NM_005767 | NM_175116 | |||||||||
| RefSeq (protein) | NP_005758 | NP_780325 | |||||||||
| Lokacija (UCSC) |
Chr 13: 47.88 - 47.89 Mb |
Chr 14: 71.97 - 71.97 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
LPAR6 (receptor lizofosfatidne kiseline 6, LPA6, P2RY5) je protein je protein koji je kod ljudi kodiran LPAR6 genom.[1][2][3][4] LPA6 je G protein-spregnuti receptor koji vezuje lipidni signalni molekul lizofosfatidnu kiselinu (LPA).[5][6]
Protein kodiran ovim genom pripada familiji G-protein spregnutih receptora, koji su preferentno aktivirani nukleotidima adenozina i uridina.[4]
- ^ Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). „Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells”. Biochim Biophys Acta. 1492 (1): 127—38. PMID 11004484.
- ^ Ralevic V, Burnstock G (1998). „Receptors for purines and pyrimidines”. Pharmacol Rev. 50 (3): 413—92. PMID 9755289.
- ^ Yanagida K, Masago K, Nakanishi H, Kihara Y, Hamano F, Tajima Y, Taguchi R, Shimizu T, Ishii S (2009). „Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6”. J Biol Chem. 284 (26): 17731—41. PMC 2719412
. PMID 19386608. doi:10.1074/jbc.M808506200.
- ^ а б „Entrez Gene: P2RY5 purinergic receptor P2Y, G-protein coupled, 5”.
- ^ Pasternack SM, von Kügelgen I, Aboud KA, Lee YA, Rüschendorf F, Voss K, Hillmer AM, Molderings GJ, Franz T, Ramirez A, Nürnberg P, Nöthen MM, Betz RC (2008). „G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth”. Nat. Genet. 40 (3): 329—34. PMID 18297070. doi:10.1038/ng.84.
- ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (2010). „LPA Receptors: Subtypes and Biological Actions”. Annual Review of Pharmacology and Toxicology. 50 (1): 157—186. PMID 20055701. doi:10.1146/annurev.pharmtox.010909.105753.
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